Transposable Elements, Transcriptomics, and Diseases (eBook)

Artikelnummer: 978-3-032-04125-8
Einband: PDF
Verfügbarkeit: Download, sofort verfügbar (Link per E-Mail)
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Transposable elements (TEs) are mobile DNA sequences once referred to as "selfish DNA". While they have contributed significantly to genome evolution, their movement can often disrupt genes and lead to disease. To counteract this, organisms have developed post-transcriptional, transcriptional, and epigenetic mechanisms to control TE activity.

This book explores the complex interplay between mobile genetic elements and human health, providing a comprehensive overview of TE biology, their modes of action, and the strategies employed to suppress their movement, and offering valuable insights into potential therapeutic interventions targeting TE-related diseases. In particular, the book reviews how TEs affect gene expression and contribute to diseases such as cancer, neurodegenerative diseases, and inherited disorders. Other topics include TE polymorphisms, epigenetic control, co-opted functions, non-coding RNAs, and their roles in environmental stress and immune pathways.

Providing a comprehensive reference on the subject, this book is intended for researchers and advanced students in genetics and related disciplines.

Transposable elements (TEs) are mobile DNA sequences once referred to as "selfish DNA". While they have contributed significantly to genome evolution, their movement can often disrupt genes and lead to disease. To counteract this, organisms have developed post-transcriptional, transcriptional, and epigenetic mechanisms to control TE activity.

This book explores the complex interplay between mobile genetic elements and human health, providing a comprehensive overview of TE biology, their modes of action, and the strategies employed to suppress their movement, and offering valuable insights into potential therapeutic interventions targeting TE-related diseases. In particular, the book reviews how TEs affect gene expression and contribute to diseases such as cancer, neurodegenerative diseases, and inherited disorders. Other topics include TE polymorphisms, epigenetic control, co-opted functions, non-coding RNAs, and their roles in environmental stress and immune pathways.

Providing a comprehensive reference on the subject, this book is intended for researchers and advanced students in genetics and related disciplines.

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VerlagSpringer International Publishing
EinbandPDF
Erscheinungsjahr2025
Seitenangabe435 S.
AusgabekennzeichenEnglisch
AbbildungenXIII, 435 p. 24 illus., 22 illus. in color.
Masse22'067 KB
PlattformPDF
ReiheEpigenetics and Human Health; Biomedical and Life Sciences; Biomedical and Life Sciences
AutorVaschetto, Luis M. (Hrsg.)

Alle Bände der Reihe "Epigenetics and Human Health; Biomedical and Life Sciences; Biomedical and Life Sciences (R0)"

Über den Autor Luis M. (Hrsg.) Vaschetto

Luis María Vaschetto obtained his Ph.D. in Biological Sciences from the Universidad Nacional de Córdoba (Argentina). He was a postdoctoral researcher at the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and a Research Associate at the South Dakota State University (SDSU). He has first-authored over ten academic articles in peer-reviewed, high-impact journals. Currently, he is a Consultant for several international companies and a Research Scholar at the Ronin Institute (RIIS 2.0). He also serves as Series Editor for the Book Series Epigenetics and Human Health (EHH), published by Springer Nature (Switzerland). Dr. Vaschetto has already edited and authored eleven international books, including four for the EHH series and three for Methods in Molecular Biology (MiMB, Springer Nature, USA). His research mainly focuses on understanding gene regulation mechanisms involved in plant and animal development, as well as their effects on human health and diseases Sameer Srivastava obtained his PhD in Biotechnology from CSIR-National Chemical Laboratory, affiliated to Savitribai Phule Pune University, Pune, (India). He was awarded prestigious Endeavour Award (Govt. of Australia) to pursue his postdoctoral studies at Lowy Cancer Research Center, University of New South Wales, Sydney, Australia. Currently he is working as Associate Professor at Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, India. He has authored more than 50 research articles in various reputed international journals and also published numerous book chapters. He also has handled various government funded project in India including, DBT, India, DST, India, ICMR, India. His research mainly focuses on understanding the epigenetic mechanisms involved in colorectal cancer development and progression. Another area of research which interests him is identifying genetic and epigenetic biomarkers in early onset-CRCs.

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