• Home /
  • Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis (eBook)

Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis (eBook)

Artikelnummer: 978-3-030-29168-6
Einband: PDF
Verfügbarkeit: Download, sofort verfügbar (Link per E-Mail)
CHF 118.00
decrease increase
This book elaborates on various aspects of targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. Many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. An overview of pathways of intracellular uptake is presented with emphasis on RME pathways. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also clinical trials, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. This section also includes a chapter on cellular assays which was conceived to provide hands on training to young and nouveau researchers in the field of targeted nanomedicine. 
This book elaborates on various aspects of targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. Many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. An overview of pathways of intracellular uptake is presented with emphasis on RME pathways. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also clinical trials, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. This section also includes a chapter on cellular assays which was conceived to provide hands on training to young and nouveau researchers in the field of targeted nanomedicine. 
Schreiben Sie Ihre eigene Bewertung
  • Nur registrierte Benutzer können Produkte bewerten
*
*
Schlecht
Sehr gut
*
*
*
*
VerlagSpringer International Publishing
EinbandPDF
Erscheinungsjahr2019
Seitenangabe560 S.
AusgabekennzeichenEnglisch
AbbildungenXVIII, 560 p. 82 illus., 45 illus. in color.
Masse10'147 KB
PlattformPDF
ReiheAAPS Advances in the Pharmaceutical Sciences Series
AutorDevarajan, Padma V. (Hrsg.) / Dandekar, Prajakta (Hrsg.) / D'Souza, Anisha A. (Hrsg.)

Alle Bände der Reihe "AAPS Advances in the Pharmaceutical Sciences Series"

Über den Autor Padma V. (Hrsg.) Devarajan

Padma V. Devarajan is Advisor and Chair Professor at the SIES School of Pharmaceutical Sciences with over three decades of experience as an academician and researcher. She was formerly Dean and Professor in Pharmacy and Member-Board of Governors, at the Institute of Chemical Technology, Mumbai, India. Her research focuses on the design and development of innovative targeted nanomedicine for cancer and infectious diseases, non-invasive bio-enhanced delivery of peptides, proteins, nucleic acids and interventions for veterinary health care. Her research addresses critical aspects such as scale-up, commercialization and affordability to ensure societal outreach. She has published extensively in peer-reviewed journals and is a reviewer for many journals. She has several patents and authored books. She is a recipient of several national and international research and innovation awards, including the Women in Science award of the Controlled Release Society Inc., USA. Dr. Sathish Dyawanapelly is an Assistant Professor at the Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India. He has a Ph.D. in pharmaceutics from the Institute of Chemical Technology, Mumbai, and a master's degree in pharmacy from the National Institute of Pharmaceutical Education and Research, Raebareli. His research area focuses on the design and development of drug delivery systems (polymer, lipid, and metal nanoparticles), biomaterials, nanomedicines, and pharmaceutical formulation technology. He has authored or co-authored numerous book chapters and published over 35 publications in peer-reviewed international journals and 3 book chapters. He developed and transferred 3 different technologies to industries. He is an Editorial member for Scientific Reports (Nature), PLOS ONE, Frontiers in Drug Delivery, Discover Pharmaceutical Sciences (Springer), and Current Indian Science (Bentham Science) and serves as a reviewer of peer-reviewed international journals. He is a member of many international scientific societies and organizations. Vijayabhaskarreddy Junnuthula is a grant-funded researcher at the University of Helsinki, Finland. His research prominently revolves around the development of nanomedicine, spanning various domains within pharmaceutical sciences, most notably pharmaceutics, pharmacokinetics, and local drug delivery for diverse therapeutic applications. He has been supported by the Finnish Cultural Foundation and was a recipient of the Marie Curie Fellowship from the European Commission under the Horizon 2020 program. He was awarded the Solvay Chair Prize at the French Society of Nanomedicine conference in Bordeaux, France. He published several high-impact journals as an author. He is a peer reviewer for several pharmaceutical science journals, such as the International Journal of Pharmaceutics, Journal of Drug Delivery Science and Technology, BMC Pharmacology, Signal Transduction, and Targeted Therapy.

Weitere Titel von Padma V. (Hrsg.) Devarajan

Produktbewertungen
Nur registrierte Benutzer können Produkte bewerten