• Home /
  • Medicines from Animal Cell Culture

Medicines from Animal Cell Culture

Artikelnummer: 978-0-470-85094-7
Einband: Fester Einband
Verfügbarkeit: Lieferbar in ca. 10-20 Arbeitstagen
CHF 430.00
decrease increase

The manufacture of medicines is an area of increasingly complex science and technology. As more diverse products are developed for the treatment of human disease, many of these cannot be made by chemical synthesis. Thus, cells of both prokaryotic and eukaryotic origin have been recruited to manufacturing processes to provide the biochemical machinery for the synthesis of natural and structurally complex molecules. This book focuses on animal cell culture, which has been used to produce human and veterinary vaccines, interferon, monoclonal antibodies and genetically engineered products such as tPA and erythropoietin. It also addresses the recent dramatic expansion in cell-based therapies, including the use of live cells for tissue regeneration. Stem cells in particular hold significant promise for future therapies and a chapter is dedicated to this topic. The book comprehensively describes the fundamentals of cell nutrition, culture, preservation and characterisation, as well as the technology and issues surrounding the production and characterisation of cell-based products. It also deals with new applications of human cells as vaccines and therapies. The regulatory framework surrounding these new applications and biological medicines in general is addressed with reference to the developing situation around the world. Standardisation and validation are key issues in all aspects of drug development: the book addresses these and includes chapters on both GLP and GMP for cell culture processes. This book is written for a wide audience to provide insight into the exciting world of biological medicines and directions for further investigation into specific topics. It will be of value to researchers and technicians at all levels using cell culture within the pharmaceutical, biotechnology and biomedical industries.

The manufacture of medicines is an area of increasingly complex science and technology. As more diverse products are developed for the treatment of human disease, many of these cannot be made by chemical synthesis. Thus, cells of both prokaryotic and eukaryotic origin have been recruited to manufacturing processes to provide the biochemical machinery for the synthesis of natural and structurally complex molecules. This book focuses on animal cell culture, which has been used to produce human and veterinary vaccines, interferon, monoclonal antibodies and genetically engineered products such as tPA and erythropoietin. It also addresses the recent dramatic expansion in cell-based therapies, including the use of live cells for tissue regeneration. Stem cells in particular hold significant promise for future therapies and a chapter is dedicated to this topic. The book comprehensively describes the fundamentals of cell nutrition, culture, preservation and characterisation, as well as the technology and issues surrounding the production and characterisation of cell-based products. It also deals with new applications of human cells as vaccines and therapies. The regulatory framework surrounding these new applications and biological medicines in general is addressed with reference to the developing situation around the world. Standardisation and validation are key issues in all aspects of drug development: the book addresses these and includes chapters on both GLP and GMP for cell culture processes. This book is written for a wide audience to provide insight into the exciting world of biological medicines and directions for further investigation into specific topics. It will be of value to researchers and technicians at all levels using cell culture within the pharmaceutical, biotechnology and biomedical industries.

Schreiben Sie Ihre eigene Bewertung
  • Nur registrierte Benutzer können Produkte bewerten
*
*
Schlecht
Sehr gut
*
*
*
*
VerlagWiley
EinbandFester Einband
Erscheinungsjahr2007
Seitenangabe696 S.
AusgabekennzeichenEnglisch
MasseH25.4 cm x B17.8 cm x D5.1 cm 1'361 g
CoverlagJohn Wiley & Sons Inc (Imprint/Brand)
AutorStacey, Glyn N. (Hrsg.) / Davis, John (Hrsg.)

Über den Autor Glyn N. (Hrsg.) Stacey

Glyn N. Stacey has a background in microbiology and cancer research and has worked on the development of cell substrates for manufacture of biological medicines for over fifteen years. He is currently at the National Institute for Biological Standards and Control which is a part of the Medicines and Healthcare Products Regulatory Agency. He is Head of Division of Cell Biology and Imaging and Director for the UK Stem Cell Bank (UKSCB). The work of his group covers safety and quality issues in cell therapy, cells used for manufacturing purposes, development of novel cell-based assays and the development of reference materials for tissue typing and diagnosis of genetic disorders. This work includes the need for scale up of preservation techniques and long term storage of DNA and cell lines of various types including human stem cell lines and cells used in bioassays and vaccine production. Tongbiao Zhao is a principal investigator at the Institute of Zoology, Chinese Academy of Sciences, where he leads the Laboratory of Stem Cell and Immunology. He also serves as Joint Deputy Dean of the Beijing Institute for Stem Cells and Regenerative Medicine and Joint Professor at the University of the Chinese Academy of Sciences. His research primarily focuses on stem cell immunology and translational stem cell research. His team has pioneered stem cell immunology; their seminal discovery of induced pluripotent stem cell immunogenicity has reshaped clinical strategies for stem cell translation, highlighting the need to induce immune tolerance. Additionally, his team has identified oxidative phosphorylation and heightened autophagic flux as intrinsic metabolic features critical for maintaining pluripotent stem cell identity. Serving as the Director of the Standard Working Committee of the Chinese Society for Cell Biology and as a member of TC276 of the International Organization for Standardization and the International Society for Stem Cell Research, he has coordinated interdisciplinary experts to develop standards supporting stem cell applications and achieved groundbreaking advancements, including the establishment of a series of seminal national and international stem cell standards.

Weitere Titel von Glyn N. (Hrsg.) Stacey

Produktbewertungen
Nur registrierte Benutzer können Produkte bewerten